Abstract
IN extending our recently published work on cell growth and the development of tumours1, we have observed that in the livers of rats fed 2-acetylamino-fluorene the cell proliferation continues at a constant rate during the pre-cancerous period arid does not decrease as we had at first supposed. Such continuous increase in a cell population at a constant rate constitutes a most unusual form of growth, and it affords an important insight into the dynamics of cell proliferation in a pre-neoplastic tissue.
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References
Laird, A. K., and Barton, A. D., Nature, 183, 1655 (1959).
Umbreit, W. W., Burris, R. H., and Stauffer, J. F., “Manometric Techniques and Related Methods for the Study of Tissue Metabolism”, 103 (Minneapolis: Burgess Publishing Co., 1945).
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Laird, A. K., and Miller, E. C., Cancer Res., 13, 464 (1953).
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LAIRD, A., BARTON, A. Cell Proliferation in Precancerous Liver: Linear Growth Curve. Nature 188, 417–418 (1960). https://doi.org/10.1038/188417a0
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DOI: https://doi.org/10.1038/188417a0
