Abstract
HEREDITARY susceptibility to hæmolysis by drugs and fava beans is believed to be due to a single sex-linked gene. This mode of inheritance would best explain the familial and population data, as summarized recently by Childs and Zinkham1. The main element of uncertainty regarding this hypothesis arises from the great variability of the measured blood abnormalities in heterozygous females (in vitro glutathione stability test and glucose-6-phosphate dehydrogenase activity).
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References
Childs, B., and Zinkham, W. H., CIBA Found. Symp. Biochem. Hum. Genet., 76 (1959).
Szeinberg, A., Sheba, C., and Adam, A., Blood, 13, 1043 (1958).
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ADAM, A. Linkage between Deficiency of Glucose-6-phosphate Dehydrogenase and Colour-blindness. Nature 189, 686 (1961). https://doi.org/10.1038/189686a0
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DOI: https://doi.org/10.1038/189686a0
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