Abstract
URINARY pH influences the excretion-rate of some weak acids and bases1,2, a more rapid excretion of weak acids occurring in alkaline urine and of weak bases in acid urine. Most of the known compounds which behave in this way are not found naturally in the body. The only endogenous substances so far described, the excretion-rate of which is dependent on urinary pH, are ammonia3 and indoleacetic acid4. We present evidence here to show that the rate of excretion of 5-hydroxytryptamine (5HT) is similarly influenced by pH, being higher in acid urine (Table 1).
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References
Milne, M. D., Scribner, B. H., and Crawford, M. A., Amer. J. Med., 24, 709 (1958).
Peters, L., Pharmacol. Rev., 12, 1 (1960).
Orloff, J., and Berliner, R. W., J. Clin. Invest., 35, 223 (1956).
Milne, M. D., Crawford, M. A., Girão, C. B., and Loughridge, L., Clin. Sci., 19, 165 (1960).
Udenfriend, S., Weissbach, H., and Clark, C. T., J. Biol. Chem., 215, 337 (1955).
Udenfriend, S., Titus, E., and Weissbach, H., J. Biol. Chem., 216, 499 (1955).
Rodnight, R., Biochem. J., 64, 621 (1956).
Brengelmann, J. C., Pare, C. M. B., and Sandler, M., J. Ment. Sci., 104, 1237 (1958).
Sandler, M., and Snow, P. J. D., Lancet, i, 137 (1958).
Despopoulos, A., and Weissbach, H., Amer. J. Physiol., 189, 548 (1957).
Woolley, D. W., Proc. U.S. Nat. Acad. Sci., 44, 1202 (1958).
Pare, C. M. B., Sandler, M., and Stacey, R. S., Lancet, ii, 1099 (1958).
Oates, J. A., Gillespie, L., Udenfriend, S., and Sjoerdsma, A., Science, 131, 1890 (1960).
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SANDLER, M., SPECTOR, R. Effect of Urinary pH on 5-Hydroxytryptamine Excretion in the Rat. Nature 189, 838–840 (1961). https://doi.org/10.1038/189838a0
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DOI: https://doi.org/10.1038/189838a0
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