Abstract
THE O-methylation of catecholamines has been shown to be an inactivation process1, but the recent characterization of melatonin (N-acetyl-5-methoxytryptamine—a potent agent in lightening frog skin) as a methoxy indole2 indicates that this may not be true with hydroxyindolealkylamines. To investigate this possibility, we have compared the actions of a number of methoxyindolealkylamines with their corresponding analogues on smooth muscle, blood pressure and behavioural patterns.
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References
Axelrod, J., Physiol. Rev., 39, 751 (1959).
Lerner, A. B., Case, J. D., and Takahashi, Y., J. Biol. Chem., 235, 1992 (1960).
Erspamer, V., Nature, 170, 281 (1952).
Barlow, R. B., and Khan, I., Brit. J. Pharm. Chemotherap., 14, 265 (1959).
Page, I. H., and Taylor, R. D., Science, 105, 622 (1947).
Fabing, H. B., and Hawkins, J. R., Science, 123, 886 (1956).
Mahler, D. S., and Humoller, F. L., Proc. Soc. Exp. Biol. and Med., 102, 697 (1959).
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GESSNER, P., McISAAC, W. & PAGE, I. Pharmacological Actions of Some Methoxyindolealkylamines. Nature 190, 179–180 (1961). https://doi.org/10.1038/190179a0
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DOI: https://doi.org/10.1038/190179a0
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