Abstract
S,β-AminoethyUsothiuronium.Br.HBr (AET) is of known value in mice, and given parenterally in an appropriate dose will convert a LD 100/30 dose of whole-body X-radiation to essentially a LD)0/30 (ref. 1). The oral administration of AET prior to X-radiation is said to be effective (ref. 2 and Doherty, D. G., personal communication), but no definite results have yet been published. Oral cysteamine has been reported to be effective in both mice and rats with a longer duration of action than intraperitoneal injection3, but this has been disputed4.
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References
Doherty, D. G., and Burnett, jun., W. T., Proc. Soc. Exp. Biol. and Med., 89, 312 (1955).
Hollaender, A., Proc. Int. Conf. Peaceful Uses of Atomic Energy, 16 (Geneva, 1955).
Bacq, Z. M., Proc. Int. Conf. Peaceful Uses of Atomic Energy, 11 (Geneva, 1955).
Langendorff, H., Koch, R., and Hagen, U., Strahlentherapie, 95, 238 (1954).
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DACQUISTO, M., BLACKBURN, E. Protective Effect of orally administered S,β-Aminoethylisothiuronium.Br.HBr against X-radiation Death in Mice. Nature 190, 270 (1961). https://doi.org/10.1038/190270a0
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DOI: https://doi.org/10.1038/190270a0
