Abstract
CLEAVAGE of the angular methyl group at carbon-10 of the testosterone molecule results in a compound that is much more potent than the parent as an œstrogen antagonist (unpublished work) and myotropic agent1, but not as an androgen1. Since 19-norprogesterone has been known as a potent progestational agent for some years2 and 18,19-dinor-testosterone has recently been synthesized by Dr. W. F. Johns, of the Division of Chemical Research, G. D. Searle and Co., these two materials have been examined as antagonists of cestrone-induced vaginal smear changes in spayed mice.
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References
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EDGREN, R. Œstrogen Antagonisms: 19-Norprogesterone and 18,19-Dinortestosterone as Œstrone Antagonists. Nature 190, 353 (1961). https://doi.org/10.1038/190353a0
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DOI: https://doi.org/10.1038/190353a0
