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Synthesis of Succinate from Acetate

Nature volume 191, page 1093 (1961)Cite this article

Abstract

IN a previous communication1, evidence was presented that an enzyme system, isolated from pig heart, catalysed the oxidation of acetate to succinate. Aconitase, assayed by the method of Racker2, was not detectable and the addition of malate to the incubation mixture did not increase the incorporation of acetate into succinate. Consequently, the formation of succinate was attributed to a Thunberg condensation and the slow rate (7 mμmoles/br./mgm. protein) was explained by the unfavourable equilibrium3.

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References

  1. Davies, D. D., Nature, 181, 339 (1958).

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  2. Racker, E., Biochim. Biophys. Acta, 4, 211 (1950).

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  3. Seaman, G. R., J. Biol. Chem., 228, 149 (1957).

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Authors and Affiliations

  1. Botany School, University of Sydney,

    D. D. DAVIES

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  1. D. D. DAVIES
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DAVIES, D. Synthesis of Succinate from Acetate. Nature 191, 1093 (1961). https://doi.org/10.1038/1911093a0

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