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Augmentation of Toxicity of Monoamine Oxidase Inhibitor by Thyroid Feeding

Nature volume 191, page 1107 (1961)Cite this article

Abstract

THE administration of desiccated thyroid or thyroxine modifies the susceptibility of animals to the poisonous effects of a number of substances. Thyroid hormone is known to increase the toxicity of fluoride1, endotoxin2, alloxan3, cocaine4, morphine5, anoxia6,7, ozone8, dinitrophenol9 and adrenaline10,11; furthermore, it prolongs the action of certain barbiturates12. Conversely, a diminished sensitivity to the toxicity of a number of nitriles has been reported13,14.

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References

  1. Phillips, P. H., English, H., and Hart, E. B., J. Nutr., 10, 399 (1935).

    Article  CAS  Google Scholar 

  2. Kroneberg, G., and Potzsch, E., Arch. Exp. Path. Pharmak., 216, 233 (1952).

    CAS  Google Scholar 

  3. Houssay, B. A., and Sara, J. G., Rev. Soc. Argent. Biol., 21, 81 (1945).

    CAS  Google Scholar 

  4. Glaubach, S., and Pick, E. P., Arch. Exp. Path. Pharmak., 162, 537 (1931).

    Article  CAS  Google Scholar 

  5. Hunt, R., and Seidell, A., J. Pharmacol., 2, 15 (1910).

    CAS  Google Scholar 

  6. Smith, A. U., Emmens, C. W., and Parkes, A. S., J. Endocrin., 5, 186 (1947).

    Article  CAS  Google Scholar 

  7. Smith, A. U., J. Endocrin., 5, 64P (1947).

    Google Scholar 

  8. Fairchild, E. J., and Stokinger, H. E., Fed. Proc., 20, 203 (1961).

    Google Scholar 

  9. Glaubach, S., and Pick, E. P., Schweiz. Med. Wschr., 64, 1115 (1934).

    CAS  Google Scholar 

  10. Kroneberg, G., and Huter, F., Klin. Wschr., 29, 649 (1951).

    Article  CAS  Google Scholar 

  11. Kroneberg, G., Arch. Exp. Path. Pharmak., 216, 240 (1952).

    CAS  Google Scholar 

  12. Conney, A. H., and Garren, L., The Pharmacologist, 2, 82 (1960).

    Google Scholar 

  13. Hunt, R., J. Biol. Chem., 1, 33 (1905).

    Google Scholar 

  14. Seyle, H., J. Clin. Exp. Psychopath. Quart. Rev. Psychiat. Neurol., 19, 97 (1958).

    Google Scholar 

  15. Taylor, J. D., Wykes, A. A., Gladish, Y. C., Martin, W. B., and Everett, G. M., Fed. Proc., 19, 278 (1960).

    Google Scholar 

  16. Taylor, J. D., Wykes, A. A., Gladish, Y. C., and Martin, W. B., Nature, 187, 941 (1960).

    Article  ADS  CAS  Google Scholar 

  17. De Beer, E. J., J. Pharmacol., 85, 1 (1945).

    CAS  Google Scholar 

  18. Spinks, A., and Burn, J. H., Brit. J. Pharmacol., 7, 93 (1952).

    PubMed  CAS  Google Scholar 

  19. Zile, M., and Lardy, H. A., Arch. Biochem. Biophys., 82, 411 (1959).

    Article  CAS  Google Scholar 

  20. Bailey, S. d'A., Bucci, L., Gosline, E., Kline, N. S., Park, I. H., Rochlin, D., Saunders, J. C., and Vaisberg, M., Ann. N.Y. Acad. Sci., 80, 652 (1959).

    Article  ADS  CAS  Google Scholar 

  21. Kline, N. S., J. Neuropsychiat., 2, 15S (1961).

    Google Scholar 

Download references

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Author notes

  1. PAUL V. BUDAY

    Present address: Medical Communication Department, Medical Research Section, Lederle Laboratories, Pearl River, New York

Authors and Affiliations

  1. Department of Pharmacology, University of Rhode Island, Kingston, Rhode Island

    RICHARD N. CARRIER & PAUL V. BUDAY

Authors
  1. RICHARD N. CARRIER
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  2. PAUL V. BUDAY
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CARRIER, R., BUDAY, P. Augmentation of Toxicity of Monoamine Oxidase Inhibitor by Thyroid Feeding. Nature 191, 1107 (1961). https://doi.org/10.1038/1911107a0

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