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Anti-Leucocyte Cytoplasm, Anti-Leucocyte Nuclei and Anti-Platelets in Disseminated Lupus Erythematosis

Abstract

THE indirect antiglobulin consumption test1,2 has been carried out on human leucocyte cytoplasm, leucocyte nuclei and platelets, using sera containing anti-leucocyte and/or platelet antibodies from non-transfused or minimally transfused patients : six disseminated lupus erythematosis (DLE), five idiopathic leuco-thrombopenias (ILT), four idiopathic thrombocytopenic purpuras (ITP). The auto-antibody nature of these substances was confirmed by the positive direct antiglobulin consumption test performed on the patients' own leucocytes and/or platelets. Three sera containing iso-leucocyte and platelet antibodies from three multiple transfused patients were also tested.

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DAUSSET, J., COLOMBANI, J. & COLOMBANI, M. Anti-Leucocyte Cytoplasm, Anti-Leucocyte Nuclei and Anti-Platelets in Disseminated Lupus Erythematosis. Nature 191, 1209–1210 (1961). https://doi.org/10.1038/1911209a0

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