Abstract
IN searching for an experimental animal which, in regard to its steroid metabolism, would be suitable for an investigation into the mechanism of action of certain synthetic steroids, particularly 19-norsteroids, we decided to use the domestic pig. A few preliminary experiments were made, during which we determined, among other things, the concentration of Zmimermann chromogens in the urine of male and female pigs and in the urine of castrated animals, while the influence of chorionic gonadotrophin and adrenocorticotrophic hormone on the excretion of Zimmermann chromogens in adult male pigs was also determined. After these preliminary experiments we started to isolate and identify the substances which produce the Zimmer-mann reaction.
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References
Dingemanse, E., Huis in 't Veld, L. G., and de Laat, B. M., J. Clin. Endocrinol., 6, 535 (1946).
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HUIS IN 'T VELD, L., LOUWERENS, B. & REILINGH, W. Neutral 17-Ketosteroids in Porcine Urine. Nature 191, 175–176 (1961). https://doi.org/10.1038/191175a0
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DOI: https://doi.org/10.1038/191175a0
