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Lack of Effect of Coenzyme Q10 on Coumarin-induced Hypoprothrombinæmia

Nature volume 191, page 711 (1961)Cite this article

Abstract

SEVERAL coumarin and indanedione drugs are capable of inducing hypoprothrombinæmia, presumably by interfering with the cofactor role of vitamin K in prothrombin synthesis. This role of vitamin K, probably involving electron transport, can be competitively inhibited by coumarins, and the inhibition competitively overcome by large doses of vitamin K (ref. 1).

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References

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  1. New York University Research Service, Goldwater Memorial Hospital, Welfare Island, New York

    MURRAY WEINER, THEODORE CHENKIN & PETER G. DAYTON

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  1. MURRAY WEINER
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  2. THEODORE CHENKIN
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  3. PETER G. DAYTON
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WEINER, M., CHENKIN, T. & DAYTON, P. Lack of Effect of Coenzyme Q10 on Coumarin-induced Hypoprothrombinæmia. Nature 191, 711 (1961). https://doi.org/10.1038/191711a0

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