Abstract
THE tuberculostatic activity of 5-(4-pyridyl)-1,3,4-oxadiazolone (S 57) has been repeatedly confirmed1–3, and complete cross-resistance with isonicotinic acid hydrazid (isoniazid) in laboratory tests using Mycobacterium tuberculosis is reported by all workers in this field. It was, therefore, a little surprising to find that, whereas isoniazid is practically inactive against human leprosy, but active against rat murine leprosy, S 57 is highly active against both animal and human leprosy4–6.
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References
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WILDER SMITH, A., BRODHAGE, H. Biological Spectrum of Some New Tuberculostatic 1,3,4-Oxadiazolones with Special Reference to Cross-Resistance and Rates of Emergence of Resistance. Nature 192, 1195 (1961). https://doi.org/10.1038/1921195a0
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DOI: https://doi.org/10.1038/1921195a0
