Abstract
DIMETHYLNITROSAMINE1 and some other dialkylnitrosamines2,3 cause centrilobular necrosis in rats. Schoental and Rose4 suggested independently that centrilobular necrosis was caused by diazo-alkanes formed by the metabolic oxidation of the nitrosamines in the liver in vivo5,6. The sequence of reactions is presumed to be: 
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Barnes, J. M., and Magee, P. N., Brit. J. Indust. Med., 11, 167 (1954).
Schmähl, D., Preussmann, R., and Hamperl, H., Naturwiss., 47, 89 (1960).
Magee, P. N. (personal communication).
Rose, R. F., The Evaluation of Drug Toxicity, 116 (Churchill, London, 1958).
Dutton, A. H., and Heath, D. F., Nature, 178, 644 (1956).
Magee, P. N., Biochem. J., 64, 676 (1956).
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HEATH, D. Mechanism of the Hepatoxic Action of Dialkylnitrosamines. Nature 192, 170 (1961). https://doi.org/10.1038/192170a0
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DOI: https://doi.org/10.1038/192170a0
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