Effects of Intraventricularly Injected Anti-N. Caudatus Antibody on the Electrical Activity of the Cat Brain

Abstract

IT is well known that anti-tissue antibodies, when injected into an animal of the donor species, may exhibit the selective affinity for the homologous organ and produce certain modifications in its morphological and functional state¹. The damaging effects of anti-tissue antibodies have been demonstrated in different organs². However, no information could be found in the literature available concerning the physiopathological events associated with an in vivo collision between anti-brain antibodies and the corresponding nervous tissue. Bearing in mind the high complexity of morphological and functional organization of the brain, a series of immuno-electro-physiological experiments has been undertaken to investigate the possible differential reactivity of various cerebral structures when exposed to the action of different brain region anti-sera. The present communication, as a part of these investigations, is a preliminary report concerning only some of the effects of intraventricularly administered anti-n. caudatus antibody on the electrical activity of various parts of the cat brain.