Abstract
COLCHICINE has been shown to inhibit deoxyribonuclease and de-phosphorylation and de-amination of deoxyribonucleotides1. The beneficial effect of colchicine in gout is possibly due to the effect of this drug on purine metabolism, since human serum nucleotidase and guinea pig liver xanthine dehydrogenase are inhibited by the alkaloid—the last-named only when given in large doses2. The purpose of the present communication is to investigate the effect of colchicine on rat liver xanthine oxidase, and on the purified enzyme.
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AFFONSO, O., MITIDIERI, E. & VILLELA, G. Effect of Colchicine on Rat Liver Xanthine Oxidase. Nature 192, 666–667 (1961). https://doi.org/10.1038/192666a0
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DOI: https://doi.org/10.1038/192666a0
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