Abstract
THE rabbit, like man, excretes 5β-pregnane-3α,20α-diol conjugated with glucuronic acid, as a urinary metabolite of exogenously administered progesterone1,2. Quantitatively, however, the 5β-pregnane-3α,20α-diol recovered accounts for no more than 10 per cent of the injected progesterone in the case of the rabbit. This observation, together with our recent identification of 20α-hydroxypregn-4-en-3-one as a urinary metabolite of the progesterone-treated rabbit, has led us to investigate the metabolic pathway by which pregnanediol is formed, and also to assess the quantitative significance of this particular pathway in terms of the overall pattern of urinary metabolites of progesterone.
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References
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ROGERS, A., THOMAS, G. Urinary Metabolites of Progesterone in the Rabbit. Nature 193, 68–69 (1962). https://doi.org/10.1038/193068a0
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DOI: https://doi.org/10.1038/193068a0
