Abstract
THE unnatural amino-acid 1-amino-cyclopentane carboxylic acid (ACPC) has been reported to inhibit the growth of Novikoff rat hepatoma1, Walker rat carcinoma 256 2, sarcoma 180 and carcinoma 755 3. Berlinguet et al.4 recently reported that this unnatural amino-acid does not undergo any metabolic change in normal rat, and so far nothing is known concerning the mechanism of its action.
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References
Martel, F., and Berlinguet, L., Canad. J. Biochem. Physiol., 37, 433 (1959).
Connors, T. A., Elson, L. A., Haddow, A., and Ross, W. C. J., Biochem. Pharm., 5, 108 (1960).
Ross, R. B., Noll, C. I., Ross, W. C. J., Nadkavni, M. V., Morrison, jun., B. H., and Bond, H. W., Med. Pharm. Chem., 3, 1 (1961).
Berlinguet, L., Bégin, Nicole, Babineau, L. M., Martel, F., Vallee, Rita, and Laferte, R. O., Proc. Fifth Intern. Cong. Biochem., Moscow, 24 (August 1961).
Vaughan, Martha, and Steinberg, D., Proc. Fourth Intern. Cong. Biochem., 8, 234 (Pergamon Press, London, 1960).
Pardee, A. B., Shore, V. G., and Prestidge, L. S., Biochim. Biophys, Acta, 21, 406 (1956).
Cowie, D. B., and Cohen, G. N., Biochim. Biophys. Acta, 26, 252 (1957).
Mickelson, M. N., Biochem. Pharm., 5, 165 (1961).
Devi, Anima, Lerman, S., and Sarkar, N., Nature, 190, 1193 (1961).
Devi, Anima, and Sarkar, N. K., Nature, 191, 1094 (1961).
Hogland, M. B., in The Nucleic Acids, edit. by Chargaff, E., and Davidson, J. N., 3, 349 (Academic Press, Inc., New York, 1960).
Pardee, A. B., Biochim. Biophys. Acta, 21, 406 (1956).
Munier, R., and Cohen, G. N., Biochim. Biophys. Acta, 31, 378 (1959).
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BERLINGUET, L., BÉGIN, N. & SARKAR, N. Mechanism of Antitumour Action of 1-Amino-Cyclopentane Carboxylic Acid. Nature 194, 1082–1083 (1962). https://doi.org/10.1038/1941082a0
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DOI: https://doi.org/10.1038/1941082a0
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