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Radiation-induced Hyperpyrexia in Rabbits

Abstract

THE response of rabbits to 25,000–50,000 r. radiation exposure is death within 3–4 hr.1. Even at lower levels of radiation exposure to 600–1,000 r. a shock like death occurs in a few animals within 24–48 hr.2. However, other biological responses which occur more consistently at these lower radiation dose-levels are depression of the white cell count and reduction in bone marrow activity3. This investigation presents evidence that a rise of body temperature is also a regular effect of acute radiation exposure in rabbits.

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References

  1. Henshaw, P. S., J. Nat. Cancer Inst., 4, 503 (1944).

    Google Scholar 

  2. Hagen, jun., C. W., and Sacher, G. A., Biological Effects of External X and Gamma Radiation, edit. by Zirkle, R. E., Chap. 7 (McGraw-Hill Book Co., Inc., New York, 1954).

    Google Scholar 

  3. Ellinger, F., Medical Radiation Biology (Charles C. Thomas, Spring-field, Illinois, 1957).

    Google Scholar 

  4. Dare, J. G., J. Pharm. Pharmacol., 5, 528 (1953).

    Article  CAS  Google Scholar 

  5. Smith, K. L., J. Pharm. Pharmacol., 6, 309 (1954).

    Article  CAS  Google Scholar 

  6. Dixon, W. J., and Massey, jun., F. J., Introduction to Statistical Analysis (McGraw-Hill Book Co., Inc., New York, 1951).

    MATH  Google Scholar 

  7. Warren, M. R., and Weiner, H. W., J. Amer. Pharm. Assoc., 35, 257 (1946).

    Article  CAS  Google Scholar 

  8. Ransom, S. W., and Ingram, W. R., Proc. Soc. Exp. Biol. and Med., 32, 1439 (1935).

    Article  Google Scholar 

  9. Pinkston, J. O., Amer. J. Physiol., 111, 539 (1935).

    Google Scholar 

  10. Guerra, F., and Brobeck, J., J. Pharmacol. Exp. Therap., 80, 209 (1944).

    CAS  Google Scholar 

Download references

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MEREDITH, O., FINNEGAN, C. Radiation-induced Hyperpyrexia in Rabbits. Nature 194, 592–593 (1962). https://doi.org/10.1038/194592a0

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