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Controller Genes in Synthesis of Human Hæmoglobin

Nature volume 194, pages 607–609 (1962)Cite this article

Abstract

MOST current accounts of gene action stress protein production as the primary gene function. Structural and functional proteins alone, however, cannot account adequately for embryological differentiation and specialized cell function. Since all cells derived from one fertilized ovum share identical genetic material, control systems must exist which govern activation and inhibition of gene action to allow complex cell functions.

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References

  1. Bradley, jun., T. B., Brawnes, J. N., and Conley, C. L., Bull. Johns Hopkins Hosp., 108, 242 (1961).

    Google Scholar 

  2. Kraus, A. P., Koch, B., and Burckett, L., Brit. Med. J., i, 1434 (1961).

  3. Thompson, R. B., Mitchener, J. W., and Huisman, H. J., Blood, 18, 267 (1961).

    CAS  PubMed  Google Scholar 

  4. Motulsky, A. G., in Trans. First Conf. Genetics, edit. by Sutton, H. B., 155 (Josiah Macy, Jr., Foundation, New York, 1960).

    Google Scholar 

  5. Ceppellini, R., in Biochemistry of Human Genetics, edit. by Wolstenholme, G. E. W., and O'Connor, C. M. (Ciba Foundation Symposiums, Boston, 1959).

    Google Scholar 

  6. Gerald, P. S., in Recent Advances in Human Genetics, edit. by Penrose, L. S. (Little, Brown and Co., Boston, 1961).

    Google Scholar 

  7. Bradley, jun., T. B., Boyer, S. H., and Allen, jun., F. H., Bull. Johns Hopkins Hosp., 108, 75 (1961).

    Google Scholar 

  8. Wheeler, J., and Krevans, J. R., Clin. Res., 9, 168 (1961) (Abst.).

    Google Scholar 

  9. Kunkel, H. G., and Wallenius, G., Science, 122, 288 (1955).

    Article  ADS  CAS  Google Scholar 

  10. Wheeler, J. T., and Krevans, J. R., Bull. Johns Hopkins Hosp., 109, 217 (1961).

    CAS  PubMed  Google Scholar 

  11. Ingram, V. M., and Stratton, A. O., Nature, 184, 1703 (1959).

    Article  Google Scholar 

  12. Baglioni, C., paper given at Amer. Assoc. Adv. Sci., Denver, 1961.

  13. Ingram, V. M., in Trans. First Conf. Genetics, edit. by Sutton, H. E., 154 (Josiah Macy Jr. Foundation, New York, 1960).

    Google Scholar 

  14. Jacob, F., Perrin, D., Sanchez, C., and Monod, J., C.R. Acad. Sci., Paris, 250, 1727 (1960).

    CAS  Google Scholar 

  15. Stockell, A., Perutz, M. F., Muirhead, H., and Glauser, S. C., J. Mol. Biol., 3, 112 (1961).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Departments of Medicine and Genetics, University of Washington, Seattle, Washington

    ARNO G. MOTULSKY

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  1. ARNO G. MOTULSKY
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MOTULSKY, A. Controller Genes in Synthesis of Human Hæmoglobin. Nature 194, 607–609 (1962). https://doi.org/10.1038/194607b0

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