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Experimental Oxidation of Hæmoglobin Effects of Irradiation in Rats

Nature volume 194, page 783 (1962)Cite this article

Abstract

THE sensitivity of human intracellular hæmoglobin to oxidation by nitrite ions is raised during growth, pregnancy in malignant disease and in some other conditions1. It has also been shown to be increased in similar circumstances in the rat2,3 and in this animal the changes appear to be related to ribo-flavin metabolism2–4. Both riboflavin deficiency5 and X-rays interfere with growth and are teratogenic. The effect of radiation on the stability of hæmoglobin against oxidation by nitrites has now been studied in the rat. A dose of 500 r. was chosen (< MLD25) and was administered at approximately 20 r./min.

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References

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  1. Department of Anatomy, University of Bristol,

    W. K. METCALF

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  1. W. K. METCALF
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METCALF, W. Experimental Oxidation of Hæmoglobin Effects of Irradiation in Rats. Nature 194, 783 (1962). https://doi.org/10.1038/194783a0

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