Slow and Fast Transferrin Variants in the Same Pedigree

Abstract

BY means of starch-gel electrophoresis Smithies^1,2 demonstrated the occurrence of distinct fast and slow variants of transferrin, the iron-binding β-globulin fraction of human serum. Several different electro-phoretically distinct transferrin components have been identified. They are termed in order of electrophoretic mobility towards the anode B₀, B_0–1, B₁, B₂, C, D₀, D₄, D₁, D₂and D₃. The discovery of the type D₄ by Harris, Penington, Robson and Scriver³ after all the other D types is the reason for the use of the designation D₄ for a transferrin migrating between D₀ and D₁ Parker and Bearn⁴ designated as B_0–1 the new variant which they recently found with a mobility intermediate between B₀ and B₁.