Response of the Hodgkin–Huxley Model to Temperature and Chemical Impulses

Abstract

TASAKI et al.^1,2 have demonstrated the existence of prolonged action potentials in the squid axon under tetraethylammonium and of a “hyperpolarizing response” of the normal squid axon in enriched potassium solutions. In a series of experiments they have evaluated the properties of the squid axon membrane in these two particular environments and were led to the conclusion that the Hodgkin–Huxley³ equations did not account for their observations, which had to be explained instead in terms of a “bistable state” hypothesis.