Relationship of Plasma Salicylate Concentration to Urinary Salicylate Excretion-Rate

Abstract

A NUMBER of workers have determined the plasma salicylate-levels in man at various time intervals after oral doses of aspirin, while others have studied salicylate excretion^1–3. However, there appear to be few reports of the concurrent determination of plasma and urine salicylate after dosage with aspirin. In this laboratory, the plasma salicylate concentrations and the urinary salicylate excretion-rates have been studied simultaneously in two groups of eight men who received a single oral dose of either aspirin B.P. or aloxiprin. (The latter is the Approved Name selected by the British Pharmacopœia Commission to describe a “polymeric condensation product of aluminium oxide and aspirin”).