Transfer of Nephrotoxic Glomerulonephritis in Rats by means of White Blood Cells

Abstract

TRANSFER of experimental glomerulonephritis on originally healthy rats has been accomplished in this and other laboratories by means of parabiosis^1,2. Transfer was observed in random-bred as well as in inbred rats, either in short-term experiments or after intervals up to 71 days between institution of nephrotoxic serum glomerulonephritis in the primarily nephritic animal, and parabiotic conjunction with the originally healthy partner^3–5. Fluorescein-labelled antisera were used to exclude the involvement of the primarily injected heterologous (rabbit) antibodies in the transfer phenomenon⁶. From these experiments it was derived that a secondary nephritis-producing factor, appearing as a consequence of the nephrotoxic serum glomerulonephritis in the circulation of the primarily nephritic rat, was transferred to the primarily healthy animal capable of attacking the corresponding organs of the latter.