Discharge of Marrow Eosinophils following Re-injection of Foreign Protein

Abstract

IN an earlier investigation¹, using the quantitative methods developed in this laboratory², it was shown that very large reserves of mature and nearly mature eosinophils are present in the bone marrow of normal guinea pigs. The question arose as to the circumstances in which these cells might be discharged, and for this reason it seemed important to carry out a quantitative investigation during the circulatory eosinophilia which follows the re-injection of foreign protein in sensitized animals. Percentage changes in bone marrow eosinophils have been noted in these conditions³.