Abstract
PREPARATIONS of soluble proteins from brain and spinal cord which were used for the production of ‘allergic’ encephalomyelitis in experimental animals have been described1–4. Roboz et al.5 reported a soluble, collagen-like protein apparently of different nature. Others6–10 have reported on the association of encephalitogenic properties with proteolipids. Although its chemical pathogenesis is unknown, the disease is almost generally accepted to be an immunological reaction and we therefore prefer to describe chemical fractions obtainable from nervous tissue as ‘encephalomyelitis-promoting’ (EP) rather than ‘encephalitogenic’.
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References
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ROBERTSON, D., BLIGHT, R. & LUMSDEN, C. Dialysable Peptide as the Causative Factor in Experimental ‘Allergic’ Encephalomyelitis. Nature 196, 1005 (1962). https://doi.org/10.1038/1961005a0
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DOI: https://doi.org/10.1038/1961005a0
