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Effect of Thiouracil on the Development of Mammary Tumours in Rats induced with 9,10-Dimethyl-1,2-Benzanthracene

Nature volume 196, page 1108 (1962)Cite this article

Abstract

THE induction of mammary tumours in rats by the oral feeding of a chemical carcinogen has been found to depend on the hormonal state of the animal1–3. This communication deals with the attempted production of such mammary tumours by the oral administration of 9,10-dimethyl-1,2-benzanthracene (DMBA) in rats made hypothyroid with propylthiouracil (PTU).

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References

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Author notes

  1. A. R. CURRIE

    Present address: Department of Pathology, University of Aberdeen,

Authors and Affiliations

  1. Division of Pathology, Imperial Cancer Research Fund, London, W.C.2

    JANET E. HELFENSTEIN, STRETTON YOUNG & A. R. CURRIE

Authors
  1. JANET E. HELFENSTEIN
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  2. STRETTON YOUNG
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  3. A. R. CURRIE
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HELFENSTEIN, J., YOUNG, S. & CURRIE, A. Effect of Thiouracil on the Development of Mammary Tumours in Rats induced with 9,10-Dimethyl-1,2-Benzanthracene. Nature 196, 1108 (1962). https://doi.org/10.1038/1961108a0

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