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Catechol-O-Methyltransferase Activity in Neuroblastoma Tumour

Nature volume 196, pages 1222–1223 (1962)Cite this article

Abstract

Von Studnitz1, Greenberg and Gardner2, and Voorhess and Gardner3 have reported marked elevations in the urinary excretion of 3-O-methylated metabolites in the urine of patients with neural tumours. It is possible that these urinary products arise mainly from O-methylation of their precursors in the liver. However, the fact that some of these patients have a normal blood pressure in the presence of a large endogenous production of norepinephrine suggested to us that metabolism of the norepinephrine may occur within the tumour.

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References

  1. von Studnitz, W., Scand. J. Clin. Lab. Invest., 12, Supp. 48 (1958).

  2. Greenberg, R. E., and Gardner, L. I., J. Clin. Invest., 39, 1729 (1960).

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  3. Voorhess, M. L., and Gardner, L. I., J. Clin. Endocrinol. Metab., 21, 321 (1961).

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  4. Axelrod, J., Albers, R. W., and Clemente, C. D., J. Neurochem., 5, 68 (1959).

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Authors and Affiliations

  1. National Institute of Mental Health,

    ELWOOD H. LABROSSE

  2. National Cancer Institute, National Institutes of Health, Bethesda, Maryland

    MYRON KARON

Authors
  1. ELWOOD H. LABROSSE
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  2. MYRON KARON
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LABROSSE, E., KARON, M. Catechol-O-Methyltransferase Activity in Neuroblastoma Tumour. Nature 196, 1222–1223 (1962). https://doi.org/10.1038/1961222a0

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