Abstract
THE chemical nature of the precursors contributing to the biosynthesis of creatine has been established as the result of in vivo experiments by Bloch et al.1,2 and DuVigneaud et al.3 as well as by the experiments with tissue slices and homogenates by Borsook and Dubnoff4–6. The last-named investigators also demonstrated that, in the mammal, the kidney is the major site of glycocyamine formation4,5; a slight transmethylating activity was also detected at this site. Baker and Miller7 also reported that the kidney is able to synthesize creatine although at a level exceeding that noted by Borsook and Dubnoff. It appears to be the present prevailing point of view that the kidney does not contribute significantly to the formation of creatine from glycocyamine8. Evidence to the contrary, derived from experiments with perfused rat kidneys and eviscerated rats, is presented in this communication.
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References
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GERBER, G., KOSZALKA, T., GERBER, G. et al. Biosynthesis of Creatine by the Kidney. Nature 196, 286–287 (1962). https://doi.org/10.1038/196286a0
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DOI: https://doi.org/10.1038/196286a0
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