Activities of Various Concentrations of Triamcinolone Acetonide

Abstract

BLANK¹ has reported that 0.01 per cent triamcinolone acetonide, applied topically, was at least comparable in clinical efficacy with 1.0 per cent hydrocortisone, although somewhat less effective than 0.1 per cent triamcinolone acetonide, the concentration usually adopted clinically. In a larger group of cases Olansky² found that 0.1 per cent triamcinolone acetonide was significantly more active than the 0.01 per cent concentration, but he quoted earlier studies³ which suggested that 0.025 per cent triamcinolone acetonide was difficult to distinguish from the 0.1 per cent concentration. Since there would be economic advantages in using a reduced concentration if this could exhibit the activity of 0.1 per cent triamcinolono acetonide in most dermatitides, we have conducted experiments to compare the effects of three concentrations of triamcinolone acetonide and 1.0 per cent hydrocortisone.