Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Enhancement of Imipramine Mortality in Hyperthyroid Mice

Nature volume 196, pages 588–589 (1962)Cite this article

Abstract

ALTHOUGH the anti-depressant drug imipramine (‘Tofranil’, Geigy) has received broad clinicalacceptance, its mode of action remains uncertain. Nevertheless, potentiation of catecholamine activity is a well-defined pharmacological effect1–3. The other major class of anti-depressant drugs, the monoamine oxidase (MAO) inhibitors, have been shown clearly to inhibit the enzyme and to elevate brain levels of monoamines4; but it is far from certain that their clinical effect is owing to this biochemical property.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Prange, A. J., Pustrom, E., and Cochrane, C. M. (in the press).

  2. Osborne, M., and Sigg, E. B., Arch. Intern. Pharmacodyn., 129, 273 (1960).

    CAS  Google Scholar 

  3. Gershon, S., et al., Arch. Gen. Psychiatry, 6, 96 (1962).

    Article  CAS  Google Scholar 

  4. Brodie, B. B., Spector, S., and Shore, P. A., Ann. N.Y. Acad. Sci., 80, 609 (1959).

    Article  ADS  CAS  Google Scholar 

  5. Board, F., Wadeson, R., and Persky, H., Arch. Neurol. and Psych., 78, 612 (1957).

    Article  CAS  Google Scholar 

  6. Carrier, R. N., and Buday, P. V., Nature, 191, 1107 (1961).

    Article  ADS  CAS  Google Scholar 

  7. Sigg, E. B., (personal communication).

  8. Prange, A. J. (in the press).

  9. Bailey, S. d'A., et al., Ann. New York Acad. Sci., 80, 652 (1959).

    Article  ADS  CAS  Google Scholar 

  10. Schreekloth, R. E., Kurland, G. S., and Freedberg, A. S., Metab., 2, 546, 555 (1953).

    Google Scholar 

  11. D'iorio, Antoine, and Leduc, Jean, Arch. Biochem. Biophys., 87, 224 (1960).

    Article  CAS  Google Scholar 

  12. Zile, M. H., and Lardy, Henry A., Arch. Biochem. Biophys., 82, 411 (1959).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Psychiatry, School of Medicine, University of North Carolina,

    ARTHUR J. PRANGE JUN. & MORRIS A. LIPTON

Authors
  1. ARTHUR J. PRANGE JUN.
    View author publications

    Search author on:PubMed Google Scholar

  2. MORRIS A. LIPTON
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

PRANGE, A., LIPTON, M. Enhancement of Imipramine Mortality in Hyperthyroid Mice. Nature 196, 588–589 (1962). https://doi.org/10.1038/196588a0

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/196588a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing