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Production of Hyaluronic Acid in Tissue Culture of Rous Sarcoma

Nature volume 196, pages 782–783 (1962)Cite this article

Abstract

ROUS chicken sarcoma has been known for a long time to produce large quantities of hyaluronic acid1–3. Rous sarcoma homogenates were shown to contain all the enzymes necessary to synthesize hyaluronic acid in vitro4. No information, however, was available as to whether or not Rous sarcoma cells produce hyaluronic acid in tissue culture as they do in the tumour. Such information may have a bearing on the question of identification of the Rous sarcoma cell. Also it was hoped to find a link between the enormous increase of hyaluronic acid synthesis in cells of a virus-induced tumour and certain aspects of virus-cell interaction, such as the increased synthesis of non-viral RNA in cells of a RNA-virus tumour.

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Authors and Affiliations

  1. Bureau of Biological Research, Rutgers, The State University, New Brunswick, New Jersey

    H. GROSSFELD

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  1. H. GROSSFELD
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GROSSFELD, H. Production of Hyaluronic Acid in Tissue Culture of Rous Sarcoma. Nature 196, 782–783 (1962). https://doi.org/10.1038/196782b0

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