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Viscosity of Single-stranded Deoxyribonucleic Acid after X-irradiation in the Native State

Abstract

SEVERAL authors1 have discussed the ionizing radiation which causes single-stranded as well as double-stranded breaks in DNA. The single-stranded breaks seem to occur more frequently. Butler's2 observation that the loss in molecular weight due to radiation is more intensive after denaturation of DNA by heating confirms this idea. The work of Doty et al.3 provides a method for separating the two DNA strands without further degrada-tion of the polynucleotide chain. I used this methodto study the radiosensitivity of the single strand DNA.

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References

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HAGEN, U. Viscosity of Single-stranded Deoxyribonucleic Acid after X-irradiation in the Native State. Nature 197, 1004–1005 (1963). https://doi.org/10.1038/1971004a0

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