Abstract
THE discovery by Stotz et al.1,2 that the injection of physiological doses of œstrogens into ovariectomized rats produces large increases in the activity of uterine peroxidase and that several tissues with high rates of cell renewal also have high peroxidase activity has aroused interest in the possible role of this enzyme in cellular proliferation and growth. In work3,4 on horseradish peroxidase, it has already been shown that this enzyme could catalyse the interaction between œstrogens and certain amino-acids and proteins under aerobic conditions, and this communication deals with a similar reaction involving the pyridine nucleotides.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Lucas, F. V., Neufeld, H. A., Utterback, J. C., Martin, A. P., and Stotz, E., J. Biol. Chem., 214, 775 (1955).
Neufeld, H. A., Levay, A. N., Lucas, F. V., Martin, A. P., and Stotz, E., J. Biol. Chem., 233, 209 (1958).
Jellinck, P. H., and Irwin, L., Nature, 192, 660 (1961).
Jellinck, P. H., and Irwin, L., Canad. J. Biochem. and Physiol., 40, 459 (1962).
Jellinck, P. H., Biochem. J., 71, 665 (1959).
Jermyn, M. A., Nature, 169, 488 (1952).
Hollander, V. P., and Stephens, M. L., J. Biol. Chem., 234, 1901 (1959).
Williams-Ashman, H. G., Cassman, M., and Klavins, M., Nature, 184, 427 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
JELLINCK, P., IRWIN, L. Interaction of Œstrogens labelled with Carbon-14 with Pyridine Nucleotide in the Presence of Peroxidase. Nature 197, 1107–1108 (1963). https://doi.org/10.1038/1971107a0
Issue date:
DOI: https://doi.org/10.1038/1971107a0
