Abstract
THE unique potentialities of high resolution nuclear magnetic resonance as a method for obtaining detailed information on molecular structure and molecular interactions in solution are well recognized1,2. However, the applicability of the method to the examination of interactions in biological systems has been hampered by its low sensitivity, requiring the use of comparatively concentrated solutions (∼ 0.05 M or higher).
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References
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JARDETZKY, O., WADE, N. & FISCHER, J. Proton Magnetic Resonance Investigation of Enzyme–Coenzyme Complexes. Nature 197, 183–184 (1963). https://doi.org/10.1038/197183a0
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DOI: https://doi.org/10.1038/197183a0
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