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Hypergammaglobulinæmia in Mink initiated by a Cell-free Filtrate

Nature volume 197, pages 206–207 (1963)Cite this article

Abstract

ALEUTIAN disease in mink is a spontaneous, transmissible disease which can be used as a model for studying the pathogenetic mechanisms in certain immunological and connective tissue diseases2. Hypergammaglobulinæmia is a constant feature of the disease1,3,5, and the severity of the natural and experimental disease appears to parallel the rise in γ-globulin2,5. The histological5,6 and histochemical7 changes resemble those of the connective tissue diseases of man. A genetic predisposition2 as well as a familial occurrence3 have been demonstrated.

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References

  1. Henson, J. B., Leader, R. W., and Gorham, J. R., Proc. Soc. Exp. Biol. Med., 107, 919 (1961).

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  2. Henson, J. B., Gorham, J. R., Leader, R. W., and Wagner, B. M. (submitted to J. Exp. Med.).

  3. Henson, J. B., Gorham, J. R., and Leader, R. W., Nat. Fur News, 34, 8 (1962).

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  4. Schackelford, R. M., Genetics of the Ranch Mink (Pilsbury Pub., Inc., New York, 1950).

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  5. Henson, J. B., Gorham, J. R., and Leader, R. W. (unpublished results).

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Authors and Affiliations

  1. Department of Veterinary Pathology, Washington State University and Animal Disease and Parasite Research Division, U.S. Department of Agriculture, Pullman, Washington

    JAMES B. HENSON, JOHN R. GORHAM & ROBERT W. LEADER

Authors
  1. JAMES B. HENSON
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  2. JOHN R. GORHAM
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  3. ROBERT W. LEADER
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HENSON, J., GORHAM, J. & LEADER, R. Hypergammaglobulinæmia in Mink initiated by a Cell-free Filtrate. Nature 197, 206–207 (1963). https://doi.org/10.1038/197206a0

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