Abstract
THE existence of a specific immunological tolerance towards host tissue antigens in radiation chimæras has been clearly demonstrated with different techniques1–3. Van Bekkum has shown that this tolerance is lost when the bone marrow of the chimæra is transferred to irradiated mice which carry antigens not related to the first host. A new tolerance was shown to develop towards the antigens of the new host which were not present in the original bone marrow donor. These findings seem to demonstrate that, for a maintenance of the tolerance, a continuous presence of antigens is required.
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References
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ZAALBERG, O., WEYZEN, W. & VOS, O. Influence of Excess of Antigen on Immunological Tolerance in Radiation Chimæras. Nature 197, 300–301 (1963). https://doi.org/10.1038/197300a0
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DOI: https://doi.org/10.1038/197300a0
