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Transfer of Stimulation of Deoxyribonucleic Acid Synthesis in Antigen-stimulated Rabbit Spleen Cell Cultures

Nature volume 197, page 608 (1963)Cite this article

Abstract

LITTLE is known about the nature of the antigenic stimulation to antibody production or the manner in which antigen reaches the necessary site of stimulation. A recent report1 implicates the sequential action of at least two different types of cells. One type is a mononucleated cell with phagocytic activity, and the other a non-phagocytic cell belonging to the lymphocytic series. Fishman suggests that an RNase sensitive material is transferred from one to the other, and it has been suggested2 that complexes between antigenic fragments and RNA may play an important part in antibody formation. A physical means whereby such a transfer might occur3,4 has been reported. This communication reports some preliminary experiments which were designed to demonstrate a transfer of antigenic stimulation from one cell culture to another.

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References

  1. Fishman, M., J. Exp. Med., 114, 837 (1961).

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  2. Campbell, D. H., and Garvey, J. S., Lab. Invest., 10, 1126 (1961).

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  3. Thiery, J. P., CIBA Found. Symp. Cellular Aspects of Immunity, edit. by Wolstenholme, G. E. W., and O'Connor, C. M., 59 (Little, Brown and Co., Boston, 1959).

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  4. Sharp, J. A., and Burwell, R. G., Nature, 188, 474 (1960).

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  5. Dutton, R. W., Eady, J. D., and Bulman, H. N., Sixteenth Ann. Symp. Fundamental Cancer Research (Univ. Texas Press, Austin, 1963).

  6. Dutton, R. W., and Eady, J. D. (to be published).

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Author notes

  1. R. W. DUTTON

    Present address: Division of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California

  2. G. HARRIS

    Present address: West Middlesex Hospital, Isleworth, Middlesex

Authors and Affiliations

  1. Department of Chemical Pathology, Postgraduate Medical School, Ducane Road, London, W.12

    R. W. DUTTON & G. HARRIS

Authors
  1. R. W. DUTTON
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  2. G. HARRIS
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DUTTON, R., HARRIS, G. Transfer of Stimulation of Deoxyribonucleic Acid Synthesis in Antigen-stimulated Rabbit Spleen Cell Cultures. Nature 197, 608 (1963). https://doi.org/10.1038/197608a0

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