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Evidence for ‘Electrogenic’ Active Sodium Transport in an Epithelial Membrane
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  • Letter
  • Published: 16 February 1963

Evidence for ‘Electrogenic’ Active Sodium Transport in an Epithelial Membrane

  • ALVIN ESSIG1,
  • HOWARD S. FRAZIER1 na1 &
  • ALEXANDER LEAF1 

Nature volume 197, page 701 (1963)Cite this article

  • 354 Accesses

  • 9 Citations

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Abstract

IN the course of active transport across the skin of a frog and the bladder of a toad, sodium moves against an electrical potential gradient both on entering and leaving the functional epithelial cell layer1,2. Transport in both tissues is dependent on the presence of potassium in the serosal medium3–5.

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References

  1. Engbaek, L., and Hoshiko, T., Acta Physiol. Scand., 39, 348 (1957).

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  2. Frazier, H. S., J. Gen. Physiol., 45, 515 (1962).

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  4. Ussing, H. H., in The Method of Isotopic Tracers Applied to the Study of Active Ion Transport (Pergamon Press, New York, 1959).

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  5. Hays, R. M., and Leaf, A., Ann. Intern. Med., 54, 700 (1961).

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  6. Koefoed-Johnsen, V., and Ussing, H. H., Acta Physiol. Scand., 42, 298 (1958).

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  7. Frazier, H. S., Dempsey, E. F., and Leaf, A., J. Gen. Physiol., 45, 529 (1962).

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  9. Frazier, H. S., and Leaf, A., J. Gen. Physiol. (in the press).

  10. Essig, A., and Leaf, A., J. Gen. Physiol. (in the press).

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Author information

Author notes
  1. HOWARD S. FRAZIER: Research Fellow, Medical Foundation, Boston, Massachusetts

Authors and Affiliations

  1. Departments of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, Mass.

    ALVIN ESSIG, HOWARD S. FRAZIER & ALEXANDER LEAF

Authors
  1. ALVIN ESSIG
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  2. HOWARD S. FRAZIER
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  3. ALEXANDER LEAF
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Cite this article

ESSIG, A., FRAZIER, H. & LEAF, A. Evidence for ‘Electrogenic’ Active Sodium Transport in an Epithelial Membrane. Nature 197, 701 (1963). https://doi.org/10.1038/197701a0

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  • Issue date: 16 February 1963

  • DOI: https://doi.org/10.1038/197701a0

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