Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Thymol Basic Ethers and Related Compounds: Central Nervous System Depressant Action

Nature volume 197, pages 969–971 (1963)Cite this article

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. The initial observation and the early pharmacology are due to Mr. M. Shapero and Miss J. W. Ross.

  2. Fourneau, E., Maderni, P., and Lestrange, Y., J. Pharm. chim., 18, 185 (1933).

    CAS  Google Scholar 

  3. Staub, A. M., and Bovet, D., C.R. Soc. Biol., 125, 818 (1937).

    CAS  Google Scholar 

  4. Staub, A. M., Ann. Inst. Pasteur, 63, 485 (1939).

    CAS  Google Scholar 

  5. Credner, K., Arzneimittelforsch., 10, 170 (1960).

    CAS  PubMed  Google Scholar 

  6. Buzas, A., Teste, J., and Frossard, J., Bull. Soc. Chim. France, 839 (1959).

  7. Buchel, L., Levy, J., and Tangay, O., C.R. Soc. Biol., 155, 2127 (1961).

    CAS  Google Scholar 

  8. This result is at variance with that quoted in ref. 6.

  9. Eddy, N. B., Chem. and Indust., 1462 (1959).

  10. Janssen, P. A. J., J. Pharm. and Pharmacol., 13, 513 (1961).

    Article  CAS  Google Scholar 

  11. Beckett, A. H., et al., J. Pharm. and Pharmacol., 8, 848, 860, 874 (1956).

    Article  CAS  Google Scholar 

  12. Ingold, K. V., and Taylor, D. R., Canad. J. Chem., 39, 471 (1961).

    Article  CAS  Google Scholar 

  13. Summarized in Steric Effects in Conjugated Systems, edit. by Gray, G. W., 100 (Butterworths Scientific Publications, London, 1958).

  14. Sharpe, C. J., and Stephens, F. F., British patent applic. 16171/60. (The Crookes Laboratories, Ltd.).

  15. Siegel, P. S., J. Physiol., 21, 226 (1946).

    Google Scholar 

  16. Dews, P. B., Brit. J. Pharmacol., 8, 46 (1953).

    CAS  PubMed  Google Scholar 

  17. Bianchi, C., Brit. J. Pharmacol., 11, 104 (1956).

    CAS  PubMed  Google Scholar 

  18. Ryall, E. W., Brit. J. Pharmacol., 17, 339 (1961).

    CAS  PubMed  Google Scholar 

  19. Macmillan, W. H., Brit. J. Pharmacol., 14, 385 (1959).

    CAS  PubMed  Google Scholar 

  20. McGeer, P. L., Boulding, J. E., Gibson, W. C., and Foulkes, R. G., J. Amer. Med. Assoc., 177, 665 (1961).

    Article  CAS  Google Scholar 

  21. Ayd, F. J., J. Amer. Med. Assoc., 175, 1054 (1961).

    Article  CAS  Google Scholar 

  22. Carlsson, A., Science, 127, 471 (1958); Pharmacol. Revs., 11, 490 (1959).

    Article  ADS  CAS  Google Scholar 

  23. Ernst, A. M., Nature, 193, 178 (1962).

    Article  ADS  CAS  Google Scholar 

  24. Martin, G. J., Brendel, R., and Beiler, J. M., Exp. Med. Surg., 8, 5 (1950).

    CAS  Google Scholar 

  25. Westermann, E., Baltzer, H., and Knell, J., Arch. exp. Path. u. Pharmakol. 234, 194 (1958).

    Article  CAS  Google Scholar 

  26. Reichle, F. A., Baldridge, R. C., Dobbs, J., and Trompetter, M., J. Amer. Med. Assoc. 178, 939 (1961).

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. C. J. SHARPE & F. F. STEPHENS

    Present address: Twyford Laboratories Ltd., Twyford Abbey Road, London, NW.10

Authors and Affiliations

  1. Research Department, Crookes Laboratories, Ltd., Park Royal, London, N.W.10

    A. ASHFORD, C. J. SHARPE & F. F. STEPHENS

Authors
  1. A. ASHFORD
    View author publications

    Search author on:PubMed Google Scholar

  2. C. J. SHARPE
    View author publications

    Search author on:PubMed Google Scholar

  3. F. F. STEPHENS
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

ASHFORD, A., SHARPE, C. & STEPHENS, F. Thymol Basic Ethers and Related Compounds: Central Nervous System Depressant Action. Nature 197, 969–971 (1963). https://doi.org/10.1038/197969a0

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/197969a0

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing