Abstract
A SIMILARITY of the mode of action of some chemical and physical agents (nitrogen mustards, ultra-violet and X-rays) has been proposed, on the basis of the similarity of many biological end-effects (pharmacological and toxicological properties, mutagenic effects, growth inhibition). Although several authors have suggested that this may be the result of reactions initiated by fundamentally different primary events, of significance to the interpretation of a common mode of action of both alkylating agents and ionizing radiations would be a description of the cross-resistance phenomenon in strains of Escherichia coli1,2.
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References
Bryson, V., Genetics, 33, 99 (1948).
Cavalli, L. L., and Visconti de Modrone, N., La Ricerca Scientifica, 18, 1569 (1948).
Puck, T. T., Marcus, P. I., and Cieciura, S. J., J. Exp. Med., 103, 273 (1955).
Whitfield, J. F., and Rixon, R. H., Exp. Cell Res., 19, 531 (1960).
Horikawa, M., Jap. J. Genetics, 36, 319 (1961).
Rhynas, P. O. W., and Newcombe, H. B., Exp. Cell Res., 21, 326 (1960).
Whitfield, J. F., and Rixon, R. H., Exp. Cell Res., 23, 412 (1961).
Levis, A. G., Spanio, L., and de Nadai, A. (in the press).
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LEVIS, A. X-Irradiation Sensitivity of Nitrogen Mustard-resistant Mammalian Cells in vitro. Nature 198, 498–499 (1963). https://doi.org/10.1038/198498a0
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DOI: https://doi.org/10.1038/198498a0
