Abstract
Two major problems are encountered when using large samples in gas chromatographic separations. First, the charge has to be placed on the column in such a manner that serious band-broadening does not occur due to slow volatilization of the sample. Secondly, the column should be operated so that peak asymmetry, resulting from the non-linear nature of the adsorption isotherm at high levels of concentration, is eliminated or counteracted.
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References
Daniel, N. W. R., and Richmond, J. W., Chem. and Indust., 1441 (1961).
Scott, R. P. W., Anal. Chem., 35, 481 (1963).
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SCOTT, R. Preparative Scale Chromatography with Analytical Columns. Nature 198, 782–783 (1963). https://doi.org/10.1038/198782b0
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DOI: https://doi.org/10.1038/198782b0
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