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Effect of Carcinogenic Polynuclear Hydrocarbons on the Metabolism of Œstrogens

Nature volume 198, page 787 (1963)Cite this article

Abstract

HUGGINS1 in 1961 showed that a single feeding of certain polynuclear aromatic hydrocarbons rapidly evoked mammary tumours in female rats and that the incidence of cancer largely depended on the hormonal status of the animals. Furthermore, Dao2 has demonstrated the failure of 3-methylcholanthrene to induce mammary cancer in male rats irrespective of the dose given and despite the fact that its concentration was the same in the mammary tissues of both sexes. Since, in addition, Conney, Miller et al.3–6 have shown that these carcinogens rapidly induce the formation of hydroxylating and other enzymes in rat liver, it was decided to investigate the fate of orally administered polynuclear hydrocarbons on the metabolism of steroid œstrogens in hepatic tissue.

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Authors and Affiliations

  1. Cancer Research Center, University of British Columbia, Vancouver, 8, Canada

    P. H. JELLINCK & LOUISE IRWIN

Authors
  1. P. H. JELLINCK
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  2. LOUISE IRWIN
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JELLINCK, P., IRWIN, L. Effect of Carcinogenic Polynuclear Hydrocarbons on the Metabolism of Œstrogens. Nature 198, 787 (1963). https://doi.org/10.1038/198787b0

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