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Effect of Melanocyte-stimulating Hormone on the Eye of the Rabbit

Abstract

THE aqueous flare is a scattering phenomenon, which may be observed when a beam of light passes the anterior chamber of the eye. It is caused by the presence of substances with large molecules (proteins). Using a photographic apparatus1 for measuring the intensity of the flare, Anjou, Krakau and Stigmar2 observed that an injection of chromatographically pure preparations of ACTH may cause an increase, sometimes quite impressive, of the flare density in normal eyes of rabbits. The maximum density occurred about 3 h after the injection; then the flare intensity faded slowly. The flare effect was regularly accompanied by a reduction of the intraocular pressure. No effect could be seen after vasopressin.

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References

  1. Anjou, C. I. N., and Krakau, C. E. T., Acta Ophthalmol., 38, 174 (1960).

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  2. Anjou, C. I. N., Krakau, C. E. T., and Stigmar, G., Acta Ophthalmol., 39, 874 (1961).

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  3. Dyster-Aas, K., and Krakau, C. E. T., Ophthalmol. (in the press).

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DYSTER-AAS, K., KRAKAU, C. Effect of Melanocyte-stimulating Hormone on the Eye of the Rabbit. Nature 199, 76 (1963). https://doi.org/10.1038/199076a0

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