Abstract
Paget, Walpole and Richardson1 described some biological effects of 1-α-methylallylthiocarbamoyl-2-methylthiocarbamoyl-hydrazine (‘ICI 33828’) in rats, dogs and monkeys and postulated a selective and reversible inhibition of pituitary gonadotrophic function. Similar results have since been obtained in mice2. In view of these findings we decided to investigate the effect of the compound on pituitary thyrotrophic function.
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References
Paget, G. W., Walpole, A. L., and Richardson, D. N., Nature, 192, 1191 (1961).
Brown, P. S., J. Endocrinol., 26, 425 (1963).
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TULLOCH, M., CROOKS, J. & BROWN, P. Inhibition of Thyroid Function by a Dithiocarbamoylhydrazine. Nature 199, 288–289 (1963). https://doi.org/10.1038/199288b0
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DOI: https://doi.org/10.1038/199288b0
