Abstract
‘REFUIN’ is a high-molecular fraction of a fermentation beer produced by a thermophilic actinomycete. The fraction is recovered by precipitation with ammonium sulphate and by fractional ice crystallization. Although the fermentation temperature is 50° C, the active principle is heat-labile, losing all activity after 6 h at room temperature. Electrophoretic analysis reveals a ninhydrin staining positively charged band.
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References
Tendler, M. D., Bull. Torrey Bot. Club, 86, 17 (1959). Tendler, M. D., and Burkholder, P. R., App. Microbiol., 9, 394 (1961).
Moore, George E., Symp. and Panel Disc., N.Y. State J. Med., 62, 2124 (1962).
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TENDLER, M., KORMAN, S. ‘Refuin’ : a Non-cytotoxic Carcinostatic Compound proliferated by a Thermophilic Actinomycete. Nature 199, 501 (1963). https://doi.org/10.1038/199501a0
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DOI: https://doi.org/10.1038/199501a0
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