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Effect of Multiple Injections of Calcium Compounds on the Survival of X-irradiated Rats

Abstract

A MODERATE increase in the survival of X-irradiated rats has been observed when either parathyroid extract or ethylenediamine tetraacetate (EDTA) was injected before or after mid-lethal doses of X-rays1–3. The action of these substances has been attributed to bone resorption, which was thought to protect the adjacent radiosensitive bone marrow by exposing it to an increased concentration of newly-released calcium. In the work recorded here, we have tested this view directly by the injection of calcium compounds.

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RIXON, R., WHITFIELD, J. Effect of Multiple Injections of Calcium Compounds on the Survival of X-irradiated Rats. Nature 199, 821–822 (1963). https://doi.org/10.1038/199821b0

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