Abstract
IT was recently reported that certain established lines of mouse fibroblasts, capable of indefinite propagation in culture1, were able to synthesize appreciable quantities of collagen2. The collagen appeared as extracellular fibres of characteristic periodicity between cells growing in multiple layers on the surface of a Petri dish. This communication examines the temporal relationship between cell growth and the expression of this differentiated function.
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References
Todaro, G., and Green, H., J. Cell Biol., 17, 299 (1963).
Goldberg, B., Green, H., and Todaro, G., Exp. Cell Res., 31, 444 (1963).
Prockop, D. J., and Udenfriend, S., Anal. Biochem., 1, 228 (1960).
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GREEN, H., GOLDBERG, B. Kinetics of Collagen Synthesis by Established Mammalian Cell Lines. Nature 200, 1097–1098 (1963). https://doi.org/10.1038/2001097a0
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DOI: https://doi.org/10.1038/2001097a0
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