Abstract
WHEN a lethal dose of endotoxin is injected intravenously into adult mongrel dogs a decline in systemic blood pressure occurs within 1 min, reaching a maximum in 5–15 min, following which irreversible shock occurs. Work in this laboratory1,2 and that of others3–5 on endotoxin shock supports the concept that the initial hæmo-dynamic alterations in dogs, rabbits and monkeys involve an antigen–antibody reaction of the anaphylactic type with the prompt reduction of complement and the appearance of increased concentrations of vasoactive substances in the blood, including histamine.
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References
Weil, M. H., and Spink, W. W., Amer. Med. Assoc. Arch. Int. Med., 101, 184 (1958).
Spink, W., and Potter, R., Fed. Proc., 22, 628 (1963).
Gilbert, V. E., and Braude, A. I., J. Exp. Med., 116, 477 (1962).
Hinshaw, L. B., Jordan, M. M., and Vick, J. A., Amer. J. Physiol., 200, 987 (1961).
Hinshaw, L. B., Emerson, jun., T. E., Iampietro, P. F., and Brake, C. M., Amer. J. Physiol., 203, 600 (1962).
Spink, W. W., and Vick, J., Circulation Res., 9, 184 (1961).
Spink, W. W., and Vick, J. A., Proc. Soc. Exp. Biol. and Med., 106, 242 (1961).
Noah, J. W., and Brand, A., J. Allergy, 32, 236 (1961).
Fox, jun., C. L., and Lasker, S. E., Amer. J. Physiol., 202, 111 (1962).
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SPINK, W., CHARTRAND, S. & DAVIS, R. Canine Endotoxin Shock: Protection against a Lethal Dose of Endotoxin following an Infusion of Histamine. Nature 200, 475 (1963). https://doi.org/10.1038/200475a0
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DOI: https://doi.org/10.1038/200475a0
