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Effects of p-Dimethylaminoazobenzene on the Fine Structure of Rat Liver Cells

Nature volume 200, pages 694–695 (1963)Cite this article

Abstract

INTEREST is at present being shown in the changes which carcinogenic agents induce in the fine structure of liver cells. When substances such as thioacetamide1, dimethylnitrosamine2 and ethionine3 are administered to rats, a constant and early change is a hypertrophy of the smooth elements of the endoplasmic reticulum. In some cells there is also the formation of whorled structures composed of smooth paired membranes. So far as p-dimethylaminoazobenzene is concerned, the only investigations reported so far are those of Porter and Bruni4, and Hübner5. These workers described a hypertrophy of the endoplasmic reticulum, but made no mention of whorl formation.

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References

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Authors and Affiliations

  1. Department of Pathology, University of Cape Town Medical School, Observatory, South Africa

    A. H. TIMME

  2. Department of Physics, University of Cape Town, Rondebosch, South Africa

    L. G. FOWLE

Authors
  1. A. H. TIMME
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  2. L. G. FOWLE
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TIMME, A., FOWLE, L. Effects of p-Dimethylaminoazobenzene on the Fine Structure of Rat Liver Cells. Nature 200, 694–695 (1963). https://doi.org/10.1038/200694a0

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